The Bureau of International Security and Nonproliferation (ISN) is a bureau within the United States Department of State responsible for managing a broad range of nonproliferation and counterproliferation functions. The bureau leads U.S. efforts to prevent the spread of weapons of mass destruction (nuclear, chemical, and biological weapons), their delivery systems, advanced conventional weapons, and related materials, technologies, and expertise.
It was created on September 13, 2005, when the Bureau of Arms Control and the Bureau of Nonproliferation were merged. Stephen G. Rademaker was the first Acting Assistant Secretary of State for International Security and Nonproliferation. He had been the Assistant Secretary for the Bureau of Arms Control, and in February 2005 he was named the head of the Bureau for Nonproliferation pending the two bureaus' merger.
^ ab"Inspection of the Bureau of International Security and Nonproliferation" (PDF). Inspector General of the Department of State. June 2015. Archived from the original (PDF) on March 8, 2016. Retrieved March 24, 2016.
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