Brockmann bodies isolated from an Atlantic wolffish. (A) Pancreatic tissues are scattered in the mesentery (black arrows). (B) The Brockmann body is indicated with an arrow.
Brockmann body is an endocrine organ in some teleost fish, and is composed of a collection of islet tissues. The islet tissues are in turn composed of endocrine cells which are the principal sites of insulin synthesis.[1] They are distributed around the spleen and the large intestine. They also secrete other hormones such as glucagon and somatostatin. Hence, Brochmann body is the centre of control of blood glucose level in these fishes. Glucagon is also produced from the intestine, but Brockmann body is the major source. Increased level of glucose stimulate the Brockmann body to release insulin, while inhibiting glucagon. Somatostatin released from Brockmann body inhibits cells to produce insulin and glucagon. In addition it inhibits release of growth hormone from the pituitary.[2] It is named after a German physician Heinrich Brochmann who discovered it in 1848.[3]
Brochmann body has gained a new attention in medical research, specifically in the management of type I diabetes mellitus. This is because the tissue is easy to harvest, and its insulin can be easily extracted. In addition, the teleost fishes can regenerate their endocrine tissues after harvest, the property of which has challenging implication in human diabetes.[4]
^Pisharath, Harshan (2009). Characterizing Endocrine Progenitors in Developing and Regenerating Zebrafish Pancreas. p. 7. ISBN 978-1-10-913251-9.
^Ostrander, Gary K. (2000). The Laboratory Fish. San Diego: Academic Press. ISBN 978-0-12-529650-2.
^Suehiro, M (1992). "Historical review of insulin and its preparations in pharmacopoeia (3). Fish insulins". Yakushigaku Zasshi (in Japanese). 27 (1): 32–39. PMID 11639701.
^Intine, Robert V.; Olsen, Ansgar S.; Sarras, Michael P. (2013). "A zebrafish model of diabetes mellitus and metabolic memory". Journal of Visualized Experiments. 72 (72): e50232. doi:10.3791/50232. PMC 3622110. PMID 23485929.
Brockmannbody is an endocrine organ in some teleost fish, and is composed of a collection of islet tissues. The islet tissues are in turn composed of...
Brockmann is a name that can be used as a given name, middle name, or surname. Andreas Brockmann (born 1967), German field hockey player Anke Brockmann...
beta cells of the pancreatic islets in most vertebrates and by the Brockmannbody in some teleost fish. Cone snails: Conus geographus and Conus tulipa...
Sources for data contained within this table have been listed within the body of the article, or where not readily available, directly from the individual...
Suzanne Brockmann (born 1960) is an American romantic fiction writer. She lives near Boston, Massachusetts, with her husband, Ed Gaffney, and their two...
Sphecoidea). Annals of the Entomological Society of America, 68, p.901-916". Brockmann, H. Jane (1980). "Brockman. J. (1980) Diversity in Nesting Behavior of...
convention". The Guardian. Archived from the original on 26 July 2023. Brockmann, Stephen (2010). A Critical History of German Film. Camden House. p. 286...
"sphexish". It is an example of a fixed action pattern, as described by H.J. Brockmann, where the sign stimulus is the sight of paralyzed prey in correct orientation...
Canadian Field-Naturalist. 134 (1): 52–55. doi:10.22621/cfn.v134i1.2413. Brockmann, H. Jane (1985). "Provisioning behavior of the great golden digger wasp...
Weapons: Fast, Furious… and Futile?". RUSI. Retrieved 3 January 2023. Brockmann, Kolja. "A matter of speed? Understanding hypersonic missile systems"...
ISBN 978-1-84457-192-5. Brockmann, Stephen (2010). A Critical History of German Film. Camden House. p. 13. ISBN 978-1-57113-468-4. Brockmann, Stephen (2010)....
Princeton University Press. p. 25. ISBN 978-0-691-14097-1. Elisabeth Brockmann: Selbsttötungen in der Bibel, in: AGUS (ed.): Kirche – Umgang mit Suizid...
Kerim (born 1948) North Macedonia EEG Sixty-second 2008 Miguel d'Escoto Brockmann (1933–2017) Nicaragua GRULAC Sixty-third 2009 Ali Treki (1937–2015) Libya...
jumping spiders are true visionaries". NBC News. 2012-10-17. Penn, Dustin; Brockmann, H. Jane (1994). "Nest-Site Selection in the Horseshoe Crab, Limulus polyphemus"...
Fathers' residence and administrative block. In early 1957, Dr. Damian Brockmann SVD constructed the first Science Block. Today in its place stands a students'...
its nest Biolib ITIS Report The digger wasp Sphex funerarius H. Jane Brockmann The control of nest depth in a digger wasp (Sphex ichneumoneus L.) Fauna...
International Mother Earth Day. General Assembly President Miguel d'Escoto Brockmann welcomed the creation of International Mother Earth Day, saying: "International...
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