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Blow fill seal information


BFS-packaged eye drops for single use

Blow-Fill-Seal, also spelled as Blow/Fill/Seal, in this article abbreviated as BFS, is an automated manufacturing process by which plastic containers, such as bottles or ampoules are, in a continuous operation, blow-formed, filled, and sealed.[1][2] It takes place in a sterile, enclosed area inside a machine, without human intervention, and thus can be used to aseptically manufacture sterile pharmaceutical or non-pharmaceutical liquid/semiliquid unit-dosage forms.[3][4] BFS is an advanced aseptic processing technology that is typically used for filling and packaging of certain sterile liquid formulations like liquid ophthalmics, inhalational anesthetics, or lavaging agents, but can also be used for injectables,[1] parenteral medicines,[5] and several other liquid or semiliquid medications,[6] with fill volumes ranging from 0.1...1000 cm³.[7][8][9] Compared against traditional glass ampoules, BFS ampoules are inexpensive, lightweight, and shatterproof.[10]

  1. ^ a b Cite error: The named reference Niazi_2020_33 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Steinbon_2005_261 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Sinclair_1995 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Bradley_1991 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Flickinger_2013_703 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference Thielen_2021_139 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference Gibson_2009_339 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference Spalding_2018_1103 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Downey_2016 was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference Amin_2010 was invoked but never defined (see the help page).

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