BPIFA1 information

BPIFA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KEG, 4KGH, 4KGO, 4N4X, 5I7K, 5I7J, 5I7L
Identifiers
Aliases	BPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDs	OMIM: 607412; MGI: 1338036; HomoloGene: 7895; GeneCards: BPIFA1; OMA:BPIFA1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,243,311 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,991,139 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; mucosa of paranasal sinus; ; trachea; ; bronchus; ; epithelium of bronchus; ; bronchial epithelial cell; ; tongue; ; superior surface of tongue; ; body of tongue;
	Top expressed in
	trachea; ; nasal epithelium; ; olfactory epithelium; ; right lung; ; right lung lobe; ; median eminence; ; vestibular membrane of cochlear duct; ; extraocular muscle; ; cochlea; ; sexually immature organism;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; protein binding; molecular function;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of single-species biofilm formation in or on host organism; multicellular organismal water homeostasis; defense response to bacterium; regulation of sodium ion transmembrane transport; antibacterial humoral response; immune system process; innate immune response; antimicrobial humoral response; regulation of liquid surface tension; immune response in nasopharyngeal-associated lymphoid tissue; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	51297
	18843
	ENSG00000198183
	ENSMUSG00000027483
	Q9NP55
	P97361
	NM_001243193; NM_016583; NM_130852
	NM_011126
	NP_001230122; NP_057667; NP_570913
	NP_035256
	Wikidata
View/Edit Human	View/Edit Mouse

BPI fold containing family A, member 1 (BPIFA1), also known as Palate, lung, and nasal epithelium clone (PLUNC),^[5] is a protein that in humans is encoded by the BPIFA1 gene.^[6]^[7] It was also formerly known as "Secretory protein in upper respiratory tracts" (SPURT). The BPIFA1 gene sequence predicts 4 transcripts (splice variants); 3 mRNA variants have been well characterized. The resulting BPIFA1 is a secreted protein, expressed at very high levels in mucosa of the airways (olfactory and respiratory and epithelium) and salivary glands; at high levels in oropharyneal epithelium, including tongue and tonsils; and at moderate levels many other tissue types and glands including pituitary, testis, lung, bladder, blood, prostate, pancreas, levels in the digestive tract (tongue, stomach, intestinal epithelium) and pancreas.^[8] The protein can be detected on the apical side of epithelial cells and in airway surface liquid, nasal mucus, and sputum.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ghafouri B (2003). "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31 (4): 810–4. doi:10.1042/bst0310810. PMID 12887311.
^ "BPIFA1 BPI fold containing family A member 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
^ Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
^ "Gene : BPIFA1 - ENSG00000198183". bgee.org. The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals.
^ "Q9NP55 - BPIA1_HUMAN". www.uniprot.org.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ghafouri-2003-5] Ghafouri B (2003). "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31 (4): 810–4. doi:10.1042/bst0310810. PMID 12887311.

[6] "BPIFA1 BPI fold containing family A member 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.

[Bingle-2001-7] Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.

[8] "Gene : BPIFA1 - ENSG00000198183". bgee.org. The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals.

[9] "Q9NP55 - BPIA1_HUMAN". www.uniprot.org.

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