dentate gyrus of hippocampal formation granule cell
cerebellar cortex
primary visual cortex
neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
peptidase inhibitor activity
cysteine-type endopeptidase inhibitor activity
metal ion binding
ubiquitin-protein transferase activity
protein binding
enzyme binding
transferase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ubiquitin protein ligase activity
Cellular component
cytoplasm
Golgi apparatus
nucleus
microtubule organizing center
cytosol
Biological process
negative regulation of peptidase activity
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic process
regulation of natural killer cell apoptotic process
mitotic spindle assembly
regulation of cell population proliferation
regulation of signal transduction
protein ubiquitination
apoptotic process
positive regulation of protein ubiquitination
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
79444
329581
Ensembl
ENSG00000101197
ENSMUSG00000038840
UniProt
Q96CA5
A2AWP0
RefSeq (mRNA)
NM_139317 NM_022161
NM_001163247
RefSeq (protein)
NP_071444 NP_647478
NP_001156719
Location (UCSC)
Chr 20: 63.24 – 63.24 Mb
Chr 2: 180.57 – 180.58 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.[5][6][7]
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.[7]
In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.[8][9]
^ abcGRCh38: Ensembl release 89: ENSG00000101197 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038840 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kasof GM, Gomes BC (May 2001). "Livin, a novel inhibitor of apoptosis protein family member". J Biol Chem. 276 (5): 3238–46. doi:10.1074/jbc.M003670200. PMID 11024045.
^Lin JH, Deng G, Huang Q, Morser J (Feb 2001). "KIAP, a novel member of the inhibitor of apoptosis protein family". Biochem Biophys Res Commun. 279 (3): 820–31. doi:10.1006/bbrc.2000.4027. PMID 11162435.
^Dynek JN, Chan SM, Liu J, et al. (2008). "Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas". Cancer Res. 68 (9): 3124–32. doi:10.1158/0008-5472.CAN-07-6622. PMID 18451137.
^Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene. The protein encoded by this gene is a member of the family of inhibitor...