Augusto Isaac d’Esaguy (Faro, Portugal 1899 - 1961) was a Portuguese medical historian who headed the Portuguese Committee of Assistance to Jewish Refugees (Commisao Portuguesa de Assistencia aos Judeos Refugiados, "COMASSIS"), a Relief Committee for the German and Polish Refugees, established in 1933, that played a crucial role in helping Jewish refugees during World War II.