Very low magnification micrograph of atypical ductal hyperplasia (ADH). The piece with ADH was circled by the pathologist with a marker, as it is so small, and sent for an additional opinion. H&E stain.
Specialty
Gynecology, pathology
Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer.[1]
The name of the entity is descriptive of the lesion; ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way, more so than usual ductal hyperplasia.
In the context of a core (needle) biopsy, ADH is considered an indication for a breast lumpectomy, also known as a surgical (excisional) biopsy, to exclude the presence of breast cancer.[2]
^"Understanding Breast Changes - National Cancer Institute". Archived from the original on May 27, 2010.
^Liberman L, Cohen MA, Dershaw DD, Abramson AF, Hann LE, Rosen PP (May 1995). "Atypical ductal hyperplasia diagnosed at stereotaxic core biopsy of breast lesions: an indication for surgical biopsy". AJR Am J Roentgenol. 164 (5): 1111–3. doi:10.2214/ajr.164.5.7717215. PMID 7717215.
and 25 Related for: Atypical ductal hyperplasia information
Atypicalductalhyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. The name of the...
focal expansion of the number of cells in a terminal breast duct, and atypicalductalhyperplasia, in which a more abnormal pattern of growth is seen, and...
increased in number. Atypicalhyperplasia is a high-risk premalignant lesion of the breast. It is believed that atypicalductalhyperplasia (ADH) is a direct...
cells to proliferations that are just short of atypicalductalhyperplasia. Usual ductalhyperplasia is typically a cohesive proliferation with haphazard...
no special type (IBC-NST), invasive ductal carcinoma (IDC), infiltrating ductal carcinoma (IDC) or invasive ductal carcinoma, not otherwise specified (NOS)...
Dipiro, P. J.; Rose, D. I.; Rhei, E.; Meyer, J. E. (2000). "AtypicalDuctalHyperplasia and Ductal Carcinoma in Situ as Revealed by Large-Core Needle Breast...
five-fold and especially high relative risk in premenopausal women. Atypicalductalhyperplasia is associated with a 2.4-fold risk. In contrast, a New England...
dehydrogenase, an enzyme Antidiuretic hormone or vasopressin Atypicalductalhyperplasia, a lesion of the breast Aalborg DH, a Danish handball club Ada...
immunohistochemical stain that can distinguish malignant from benign biliary ductal tissue, although staining for cytokeratins, carcinoembryonic antigen, and...
of developing breast cancer. Examples include atypicalductalhyperplasia, atypical lobular hyperplasia, and intraductal papillomas. Benign proliferative...
ovarian cancer Venous thrombosis History of uterine fibroids Atypicalductalhyperplasia of the breast Active gallbladder disease (cholangitis, cholecystitis)...
group is invasive ductal carcinoma, representing about 80% of invasive carcinomas. In the US, 55% of breast cancers are invasive ductal carcinoma. Invasive...
PTEN (causes Cowden syndrome), and PALB1. Breast changes like atypicalductalhyperplasia found in benign breast conditions such as fibrocystic breast...
coincides with the progression of ductal neoplasia to ductal carcinoma in situ and invasive carcinoma. Rarely, terminal ducts may be involved in lobular neoplasia...
calponin in ductal carcinoma in situ, highlighting myoepithelial cells around all tumor cells, thereby ruling out invasive ductal carcinoma. Ductal carcinoma...
lesions like lobular carcinoma in situ (LCIS), atypicalductalhyperplasia (ADH) and atypical lobular hyperplasia (ALH). Having dense breasts or breasts with...
important to correctly identify, as it can be confused with atypicalductalhyperplasia, cribriform ductal carcinoma in situ (DCIS), and adenoid cystic carcinoma...
bacteria, neutrophils and inspissated fluid in lumen of ductal structures. Damage to ductal epithelium results in sialodochitis (periductal inflammation)...
presence of a hyperplasia. Within ten years, 8–30% of atypical endometrial hyperplasias develop into cancer, whereas 1–3% of non-atypicalhyperplasias do so....
ductal development at puberty. In addition, mice modified to have overexpression of PRA display ductalhyperplasia, and progesterone induces ductal growth...
to the allergen. Migratory stomatitis (or geographic stomatitis) is an atypical presentation of a condition which normally presents on the tongue, termed...
factor for the development of breast cancer, family history, or atypical lobular hyperplasia (when irregular cells line the milk lobes.) This type of procedure...
syndrome, partial X chromosome deletions, lipoid congenital adrenal hyperplasia, and Turner syndrome. Upon diagnosis, estrogen and progestogen therapy...
Global Information