Atlastin information

Atlastins (ATLs) are a class of endoplasmic reticulum (ER) GTPases. Invertebrates have a single ATL, while vertebrates possess three ATL proteins (ATL1-3) that are differentially expressed.^[1] ATL1 is the predominant paralog of the central nervous system, whereas ATL2 and ATL3 are mainly expressed in tissues outside of the CNS.^[1] Loss of all ATLs in mammalian cells dramatically impacts ER structure, including a reduction in tubule three-way junctions.^[2]

^ ^a ^b Rismanchi N, Soderblom C, Stadler J, Zhu PP, Blackstone C (June 2008). "Atlastin GTPases are required for Golgi apparatus and ER morphogenesis". Human Molecular Genetics. 17 (11): 1591–1604. doi:10.1093/hmg/ddn046. PMC 2902292. PMID 18270207.
^ Zhao G, Zhu PP, Renvoisé B, Maldonado-Báez L, Park SH, Blackstone C (November 2016). "Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology". Experimental Cell Research. 349 (1): 32–44. doi:10.1016/j.yexcr.2016.09.015. PMID 27669642.

[:0-1] Rismanchi N, Soderblom C, Stadler J, Zhu PP, Blackstone C (June 2008). "Atlastin GTPases are required for Golgi apparatus and ER morphogenesis". Human Molecular Genetics. 17 (11): 1591–1604. doi:10.1093/hmg/ddn046. PMC 2902292. PMID 18270207.

[2] Zhao G, Zhu PP, Renvoisé B, Maldonado-Báez L, Park SH, Blackstone C (November 2016). "Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology". Experimental Cell Research. 349 (1): 32–44. doi:10.1016/j.yexcr.2016.09.015. PMID 27669642.

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