The Apostolic Vicariate of Makokou (French: Vicariat apostolique de Makokou) is the last Roman Catholic missionary jurisdiction in Gabon, Equatorial Africa, as the rest of the country forms the ecclesiastical province of the Metropolitan Archbishop of Libreville. The vicariate is directly under authority of the Holy See and its Dicastery for Evangelization.
Its episcopal seat is the Cathédrale Notre-Dame des Victoires, devoted to Our Lady of Victory, in Makokou, the regional capital of the Ogooué-Ivindo province in northern Gabon.