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Anders Martin Dale is a prominent neuroscientist and professor of radiology, neurosciences, psychiatry, and cognitive science at the University of California, San Diego (UCSD),[1] and is one of the world's leading developers of sophisticated computational neuroimaging techniques.[2][3] He is the founding Director of the Center for Multimodal Imaging Genetics (CMIG) at UCSD.[4]
Dale founded and initially developed the brain imaging analysis software FreeSurfer as a graduate student at UCSD.[5] He later co-developed FreeSurfer at Massachusetts General Hospital/Harvard Medical School with Bruce Fischl.[6] In addition to FreeSurfer, his major scientific contributions include developing: a) event related functional magnetic resonance imaging (fMRI) (with Randy Buckner at Harvard),[7] b) an in vivo method to quantify the gray matter thickness of the cerebral cortex using MRI images (with Bruce Fischl at Harvard),[8] c) an analysis platform to combine fMRI with magnetoencephalography (MEG),[9] d) computational morphometry to automatically label brain regions using MRI scans (with Bruce Fischl at Harvard and Rahul Desikan and Ron Killiany at Boston University),[10][11] and e) MRI-based methodologies to quantify longitudinal change in brain regions (with Dominic Holland at UCSD).[12]
Since 2013, in collaboration with Ole Andreassen at the University of Oslo, and using GWAS summary statistics (p-values and odds ratios), Dale has developed and validated methods for evaluating genetic overlap (pleiotropy) across diseases and phenotypes.[13] These genetic pleiotropy methods have provided valuable insights across a number of diseases and identified novel single nucleotide polymorphisms associated with increased risk for schizophrenia, bipolar disorder,[14] Alzheimer's disease,[15] Parkinson's disease, frontotemporal dementia,[16] corticobasal degeneration,[17] hypertension, hypercholesterolemia and coronary artery disease.[18] In collaboration with Rahul Desikan and Chun Fan, Dale has developed a polygenic score for quantifying the 'personalized' risk for quantifying Alzheimer's disease age of onset.[19]
- ^ "UCSD profile". Archived from the original on 2011-07-20.
- ^ "Stimulus Grant of Nearly $9 Million to UC San Diego Funds Big Study of Young Brains". UCSD News.
- ^ "Anders Dale". LinkedIn.
- ^ "MMIL Webpage".
- ^ Dale, Anders M.; Sereno, Martin I. (1993). "Improved Localizadon of Cortical Activity by Combining EEG and MEG with MRI Cortical Surface Reconstruction: A Linear Approach". Journal of Cognitive Neuroscience. 5 (2): 162–76. doi:10.1162/jocn.1993.5.2.162. PMID 23972151. S2CID 39212171.
- ^ Dale, Anders M.; Fischl, Bruce; Sereno, Martin I. (1999). "Cortical Surface-Based Analysis". NeuroImage. 9 (2): 179–94. doi:10.1006/nimg.1998.0395. PMID 9931268. S2CID 2807360.
- ^ Dale, Anders M.; Buckner, Randy L. (1997). "Selective averaging of rapidly presented individual trials using fMRI". Human Brain Mapping. 5 (5): 329–40. doi:10.1002/(SICI)1097-0193(1997)5:5<329::AID-HBM1>3.0.CO;2-5. PMID 20408237. S2CID 6401373.
- ^ Fischl, B.; Dale, A. M. (2000). "Measuring the thickness of the human cerebral cortex from magnetic resonance images". Proceedings of the National Academy of Sciences. 97 (20): 11050–5. Bibcode:2000PNAS...9711050F. doi:10.1073/pnas.200033797. JSTOR 123250. PMC 27146. PMID 10984517.
- ^ Dale, Anders M.; Liu, Arthur K.; Fischl, Bruce R.; Buckner, Randy L.; Belliveau, John W.; Lewine, Jeffrey D.; Halgren, Eric (2000). "Dynamic Statistical Parametric Mapping". Neuron. 26 (1): 55–67. doi:10.1016/S0896-6273(00)81138-1. PMID 10798392. S2CID 16039084.
- ^ Fischl, Bruce; Salat, David H.; Busa, Evelina; Albert, Marilyn; Dieterich, Megan; Haselgrove, Christian; Van Der Kouwe, Andre; Killiany, Ron; Kennedy, David; Klaveness, Shuna; Montillo, Albert; Makris, Nikos; Rosen, Bruce; Dale, Anders M. (2002). "Whole Brain Segmentation". Neuron. 33 (3): 341–55. doi:10.1016/S0896-6273(02)00569-X. PMID 11832223. S2CID 9629554.
- ^ Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce; Quinn, Brian T.; Dickerson, Bradford C.; Blacker, Deborah; Buckner, Randy L.; Dale, Anders M.; Maguire, R. Paul; Hyman, Bradley T.; Albert, Marilyn S.; Killiany, Ronald J. (2006). "An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest". NeuroImage. 31 (3): 968–80. doi:10.1016/j.neuroimage.2006.01.021. PMID 16530430. S2CID 12420386.
- ^ Holland, D.; Brewer, J. B.; Hagler, D. J.; Fennema-Notestine, C.; Dale, A. M. (2009). "Subregional neuroanatomical change as a biomarker for Alzheimer's disease". Proceedings of the National Academy of Sciences. 106 (49): 20954–9. Bibcode:2009PNAS..10620954H. doi:10.1073/pnas.0906053106. PMC 2791580. PMID 19996185.
- ^ Andreassen, O. A.; Djurovic, S; Thompson, W. K.; Schork, A. J.; Kendler, K. S.; O'Donovan, M. C.; Rujescu, D; Werge, T; Van De Bunt, M; Morris, A. P.; McCarthy, M. I.; International Consortium for Blood Pressure GWAS.; Diabetes Genetics Replication Meta-analysis Consortium.; Psychiatric Genomics Consortium Schizophrenia Working Group.; Roddey, J. C.; McEvoy, L. K.; Desikan, R. S.; Dale, A. M. (2013). "Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors". The American Journal of Human Genetics. 92 (2): 197–209. doi:10.1016/j.ajhg.2013.01.001. PMC 3567279. PMID 23375658.
- ^ Andreassen, Ole A.; Thompson, Wesley K.; Schork, Andrew J.; Ripke, Stephan; Mattingsdal, Morten; Kelsoe, John R.; Kendler, Kenneth S.; O'Donovan, Michael C.; Rujescu, Dan; Werge, Thomas; Sklar, Pamela; Roddey, J. Cooper; Chen, Chi-Hua; McEvoy, Linda; Desikan, Rahul S.; Djurovic, Srdjan; Dale, Anders M. (2013). "Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate". PLOS Genetics. 9 (4): e1003455. doi:10.1371/journal.pgen.1003455. PMC 3636100. PMID 23637625.
- ^ Desikan, R. S.; Schork, A. J.; Wang, Y.; Thompson, W. K.; Dehghan, A.; Ridker, P. M.; Chasman, D. I.; McEvoy, L. K.; Holland, D.; Chen, C.-H.; Karow, D. S.; Brewer, J. B.; Hess, C. P.; Williams, J.; Sims, R.; O'Donovan, M. C.; Choi, S. H.; Bis, J. C.; Ikram, M. A.; Gudnason, V.; Destefano, A. L.; Van Der Lee, S. J.; Psaty, B. M.; Van Duijn, C. M.; Launer, L.; Seshadri, S.; Pericak-Vance, M. A.; Mayeux, R.; Haines, J. L.; et al. (2015). "Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease". Circulation. 131 (23): 2061–2069. doi:10.1161/CIRCULATIONAHA.115.015489. PMC 4677995. PMID 25862742.
- ^ Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witeolar, Aree; Karch, Celeste M; Schork, Andrew J; Fan, Chun C; Brewer, James B; Momeni, Parastoo; Schellenberg, Gerard D; Dillon, William P; Sugrue, Leo P; Hess, Christopher P; Yokoyama, Jennifer S; Bonham, Luke W; Rabinovici, Gil D; Miller, Bruce L; Andreassen, Ole A; Dale, Anders M; Hardy, John; Desikan, Rahul S (2017). "Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases". Journal of Neurology, Neurosurgery & Psychiatry. 88 (2): 152–164. doi:10.1136/jnnp-2016-314411. PMC 5237405. PMID 27899424.
- ^ Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi; Ross, Owen A.; Rademakers, Rosa; Kim, Jungsu; Wang, Yunpeng; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Momeni, Parastoo; Sugrue, Leo P.; Hess, Christopher P.; James Barkovich, A.; Boxer, Adam L.; Seeley, William W.; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Schmansky, Nicholas J.; Fischl, Bruce; Hyman, Bradley T.; Dickson, Dennis W.; Schellenberg, Gerard D.; Andreassen, Ole A.; Dale, Anders M.; Desikan, Rahul S. (2017). "Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia". Acta Neuropathologica. 133 (5): 825–837. doi:10.1007/s00401-017-1693-y. PMC 5429027. PMID 28271184.
- ^ Leblanc, Marissa; Zuber, Verena; Andreassen, Bettina Kulle; Witoelar, Aree; Zeng, Lingyao; Bettella, Francesco; Wang, Yunpeng; McEvoy, Linda K.; Thompson, Wesley K.; Schork, Andrew J.; Reppe, Sjur; Barrett-Connor, Elizabeth; Ligthart, Symen; Dehghan, Abbas; Gautvik, Kaare M.; Nelson, Christopher P.; Schunkert, Heribert; Samani, Nilesh J.; Ridker, Paul M; Chasman, Daniel I.; Aukrust, Pål; Djurovic, Srdjan; Frigessi, Arnoldo; Desikan, Rahul S.; Dale, Anders M.; Andreassen, Ole A.; Andreassen, O. A. (2016). "Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes with Several Cardiovascular Risk Factors Novelty and Significance". Circulation Research. 118 (1): 83–94. doi:10.1161/CIRCRESAHA.115.306629. PMC 5609485. PMID 26487741.
- ^ Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J.; Cabral, Howard J.; Cupples, L. Adrienne; Thompson, Wesley K.; Besser, Lilah; Kukull, Walter A.; Holland, Dominic; Chen, Chi-Hua; Brewer, James B.; Karow, David S.; Kauppi, Karolina; Witoelar, Aree; Karch, Celeste M.; Bonham, Luke W.; Yokoyama, Jennifer S.; Rosen, Howard J.; Miller, Bruce L.; Dillon, William P.; Wilson, David M.; Hess, Christopher P.; Pericak-Vance, Margaret; Haines, Jonathan L.; Farrer, Lindsay A.; Mayeux, Richard; Hardy, John; Goate, Alison M.; et al. (2017). "Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score". PLOS Medicine. 14 (3): e1002258. doi:10.1371/journal.pmed.1002258. PMC 5360219. PMID 28323831.