Micrograph of an ameloblastoma showing the characteristic palisading and stellate reticulum. H&E stain.
Specialty
Oncology, oral and maxillofacial surgery
Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium (ameloblasts, or outside portion, of the teeth during development) much more commonly appearing in the lower jaw than the upper jaw.[1] It was recognized in 1827 by Cusack.[2] This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the French physician Louis-Charles Malassez.[3] It was finally renamed to the modern name ameloblastoma in 1930 by Ivey and Churchill.[4][5]
While these tumors are rarely malignant or metastatic (that is, they rarely spread to other parts of the body), and progress slowly, the resulting lesions can cause severe abnormalities of the face and jaw leading to severe disfiguration. Additionally, as abnormal cell growth easily infiltrates and destroys surrounding bony tissues, wide surgical excision is required to treat this disorder. If an aggressive tumor is left untreated, it can obstruct the nasal and oral airways making it impossible to breathe without oropharyngeal intervention. The term "ameloblastoma" is from the early English word amel, meaning enamel and the Greek word blastos, meaning germ.[6]
^Reichart PA, Philipsen HP, Sonner S (March 1995). "Ameloblastoma: biological profile of 3677 cases". European Journal of Cancer, Part B. 31B (2): 86–99. doi:10.1016/0964-1955(94)00037-5. PMID 7633291.
^Cusack JW (1827). "Report of the amputations of the lower jaw". Dublin Hosp Rec. 4: 1–38.
^Malassez L (1885). "Sur Le role des debris epitheliaux papdentaires". Arch Physiol Norm Pathol. 5: 309–340 6:379–449.
^Ivey RH, Churchill HR (1930). "The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin". Am Assoc Dent Sch Trans. 7: 240–245.
^Madhup R, Kirti S, Bhatt ML, Srivastava M, Sudhir S, Srivastava AN (January 2006). "Giant ameloblastoma of jaw successfully treated by radiotherapy". Oral Oncology Extra. 42 (1): 22–25. doi:10.1016/j.ooe.2005.08.004.
^Brazis PW, Miller NR, Lee AG, Holliday MJ (1995). "Neuro-ophthalmologic Aspects of Ameloblastoma". Skull Base Surgery. 5 (4): 233–44. doi:10.1055/s-2008-1058921. PMC 1656531. PMID 17170964.
Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium (ameloblasts, or outside portion, of the teeth during development) much more...
modern name ameloblastoma in 1930 by Ivey and Churchill. Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas. However...
called an ameloblastoma on its lower jaw. The presence of this benign tumor in a dinosaur is a first, as before the discovery, ameloblastomas were known...
Erdheim–Chester disease (a non-Langerhans-cell histiocytosis) and ameloblastoma. The mechanism of the mutation is that the negative charge of the acidic...
by a benign odontogenic cyst becoming malignant, or a pre-existing ameloblastoma. Chemotherapy has not proven effective in treating ameloblastic carcinoma...
about 30 Hounsfield units, which is about the same as ameloblastomas. However, ameloblastomas show more bone expansion and seldom show high density areas...
Cleveland's death that the tumor was a carcinoma. Other suggestions included ameloblastoma or a benign salivary mixed tumor (also known as a pleomorphic adenoma)...
undergo neoplastic transformation to an ameloblastoma has been well-documented. Mourshed showed that 33% of ameloblastomas arose from the epithelial lining of...
the second most frequent type of odontogenic tumor worldwide (after ameloblastoma), accounting for about 20% of all cases within this relatively uncommon...
It was previously described as an adenoid adamantoblastoma, unusual ameloblastoma and a cystic odontoma. Like other odontogenic neoplasms, it is thought...
His 2017 work was a retrospective study comparing recurrence rates of ameloblastoma following conservative and radical treatments, revealing a significantly...
, 2016. A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record. Scientific reports, 6. doi:10.1038/srep29271 Hendrickx...
and they gave us laughter in writing them." She was diagnosed with ameloblastoma, a tumor-forming bone disease, and died 11 months after her diagnosis...
2008). "Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor". The American Journal of Surgical...
are recognized: Adamantinomatous craniopharyngiomas, which resemble ameloblastomas (the most common type of odontogenic tumor), are characterized by activating...
tissue could be confused with the most common odontogenic tumour, the Ameloblastoma. Therefore the mesenchymal component is histologically important in...
hysterectomy. On September 28, 2010, she went on hiatus to undergo surgery for ameloblastoma on the right half of her upper jawbone. On December 31, 2010, she reported...
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