Alkylglycerone phosphate synthase information

alkylglycerone phosphate synthase
alkylglycerone phosphate synthase
Identifiers
Symbol	AGPS
NCBI gene	8540
HGNC	327
OMIM	603051
RefSeq	NM_003659
UniProt	O00116
Other data
EC number	2.5.1.26
Locus	Chr. 2 q31
Structures
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Structures	Swiss-model
Domains	InterPro

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alkylglycerone-phosphate synthase
alkylglycerone-phosphate synthase
Identifiers
EC no.	2.5.1.26
CAS no.	64060-42-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

Alkylglycerone phosphate synthase (EC 2.5.1.26, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetone phosphate synthetase, alkyl DHAP synthetase, alkyl-DHAP, dihydroxyacetone-phosphate acyltransferase, DHAP-AT) is an enzyme associated with Type 3 Rhizomelic chondrodysplasia punctata.^[1]^[2] This enzyme catalyses the following chemical reaction

1-acyl-glycerone 3-phosphate + a long-chain alcohol

\rightleftharpoons

an alkyl-glycerone 3-phosphate + a long-chain acid anion

^ Brown AJ, Snyder F (August 1982). "Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism". The Journal of Biological Chemistry. 257 (15): 8835–9. doi:10.1016/S0021-9258(18)34205-4. PMID 7096336.
^ Wykle RL, Plantadosi C, Snyder F (May 1972). "The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor". The Journal of Biological Chemistry. 247 (9): 2944–8. doi:10.1016/S0021-9258(19)45301-5. PMID 4401994.

[1] Brown AJ, Snyder F (August 1982). "Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism". The Journal of Biological Chemistry. 257 (15): 8835–9. doi:10.1016/S0021-9258(18)34205-4. PMID 7096336.

[2] Wykle RL, Plantadosi C, Snyder F (May 1972). "The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor". The Journal of Biological Chemistry. 247 (9): 2944–8. doi:10.1016/S0021-9258(19)45301-5. PMID 4401994.