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Alexei Kharitonenkov (Russian: Алексей Игоревич Харитоненков) is a Russian-American researcher best known for his discoveries of endocrine functions of Fibroblast Growth Factor 21 (FGF21) and its prospects in developing novel therapies for metabolic diseases.[1][2][3] He is also known for his landmark identification of the signal-regulatory family of proteins (SIRPs),[4] and their corresponding protein-tyrosine phosphatases,[5] which helped unveil the molecular machinery of immune self-recognition (“do-not-eat me” signal) and their potential for the development of drugs to fight cancer.[6][7][8][9][10]

  1. ^ Eisenstein, Michael (2005-06-01). "Growth factor discovery promises advance in diabetes research". Lab Animal. 34 (6): 10. doi:10.1038/laban0605-10b. ISSN 0093-7355. PMID 15924117. S2CID 31988407.
  2. ^ Seaborg, Eric (2013-04-01). "Metabolic Breakthrough". Endocrine News. Retrieved 2022-11-13.
  3. ^ She, Qin-Ying; Li, Li-Juan; Liu, Ming-Hong; Tan, Ru-Yu; Zhong, Yi-Wen; Bao, Jing-Fu; Xie, Jie-Dong (2022). "Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021". Frontiers in Pharmacology. 13: 1011008. doi:10.3389/fphar.2022.1011008. ISSN 1663-9812. PMC 9551462. PMID 36238554.
  4. ^ Kharitonenkov, A.; Chen, Z.; Sures, I.; Wang, H.; Schilling, J.; Ullrich, A. (1997-03-13). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–186. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. ISSN 0028-0836. PMID 9062191. S2CID 4259314.
  5. ^ "Google Scholar". scholar.google.es. Retrieved 2022-11-13.
  6. ^ Cambier, J. C. (1997-06-10). "Inhibitory receptors abound?". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 5993–5995. Bibcode:1997PNAS...94.5993C. doi:10.1073/pnas.94.12.5993. ISSN 0027-8424. PMC 33673. PMID 9177155.
  7. ^ Lai, Lisa A.; Zhao, Chunmei; Zhang, Eric E.; Feng, Gen-Sheng (2004), Ariño, Joaquí n; Alexander, Denis R. (eds.), "The Shp-2 tyrosine phosphatase", Protein Phosphatases, vol. 5, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 275–299, doi:10.1007/978-3-540-40035-6_14, ISBN 978-3-540-20560-9, retrieved 2022-11-13
  8. ^ Hendriks, Wiljan J. A. J.; Böhmer, Frank-D (2016), Neel, Benjamin G.; Tonks, Nicholas K. (eds.), "Non-transmembrane PTPs in Cancer", Protein Tyrosine Phosphatases in Cancer, New York, NY: Springer New York, pp. 47–113, doi:10.1007/978-1-4939-3649-6_3, ISBN 978-1-4939-3647-2, retrieved 2022-11-13
  9. ^ Bence, Kendra K. (2016), Neel, Benjamin G.; Tonks, Nicholas K. (eds.), "Protein-Tyrosine Phosphatases: Linking Metabolism and Cancer", Protein Tyrosine Phosphatases in Cancer, New York, NY: Springer New York, pp. 307–333, doi:10.1007/978-1-4939-3649-6_12, ISBN 978-1-4939-3647-2, retrieved 2022-11-13
  10. ^ Leo, Manuela; Sabatino, Lina (2022-10-18). "Targeting CXCR4 and CD47 Receptors: An Overview of New and Old Molecules for a Biological Personalized Anticancer Therapy". International Journal of Molecular Sciences. 23 (20): 12499. doi:10.3390/ijms232012499. ISSN 1422-0067. PMC 9604048. PMID 36293358.

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