Afterdepolarizations are abnormal depolarizations of cardiac myocytes that interrupt phase 2, phase 3, or phase 4 of the cardiac action potential in the electrical conduction system of the heart. Afterdepolarizations may lead to cardiac arrhythmias. Afterdepolarization is commonly a consequence of myocardial infarction, cardiac hypertrophy, or heart failure.[1] It may also result from congenital mutations associated with calcium channels and sequestration.[2]
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electrical conduction system of the heart. Afterdepolarizations may lead to cardiac arrhythmias. Afterdepolarization is commonly a consequence of myocardial...
ventricular action potential and evaluate the likelihood for early afterdepolarization to occur. In the last years, in silico medicine turned out to be...
socket Eadem, a Latin term meaning "the same", abbreviated ead. Early afterdepolarization, a type of cardiac dysrhythmia Earlsfield railway station in London...
(sAHP) state can be followed by an afterdepolarized state (which is not to be confused with the cardiac afterdepolarization) and can thus set the phase of...
associated with LQTS. Since the cause of arrhythmias in LQTS is early afterdepolarizations (EADs), and they are increased in states of adrenergic stimulation...
lidocaine suppresses digoxin-induced ventricular automaticity and delay afterdepolarizations without depressing AV conduction. In the case of an abnormally slow...
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the myocardial action potential, magnesium suppresses the early afterdepolarizations that occur in this phase with calcium influx into the cell. The phenomenon...
"Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts"...
needed] This increases the susceptibility of the myocardium to early Afterdepolarizations (EADs) at low heart rates.[citation needed] Antiarrhythmic agents...
Zhilin (2009). "Bifurcation and Chaos in a Model of Cardiac Early Afterdepolarizations". Phys Rev Lett. 102 (25): 258103. Bibcode:2009PhRvL.102y8103T. doi:10...
occur when calcium is not properly exported by NCX, causing delayed afterdepolarizations and triggering abnormal activity that can possibly lead to atrial...
ion channel Activating function Active transport Adolf Eugen Fick Afterdepolarization Aggregate modulus Aharon Katzir Alan Lloyd Hodgkin Alexander Rich...
Institute researchers showed that oscillatory after potentials (delayed afterdepolarizations) was the basis for arrhythmias associated with digitalis toxicity...
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