regulation of cardiac muscle contraction by calcium ion signaling
response to hypoxia
positive regulation of ATP-dependent activity
cardiac muscle contraction
positive regulation of sodium ion export across plasma membrane
sodium ion transport
cellular sodium ion homeostasis
sodium ion export across plasma membrane
metal ion transport
cell communication by electrical coupling involved in cardiac conduction
protein stabilization
positive regulation of potassium ion import across plasma membrane
cellular calcium ion homeostasis
ion transport
cellular potassium ion homeostasis
potassium ion transport
membrane repolarization
ion transmembrane transport
ATP metabolic process
cell adhesion
regulation of gene expression
positive regulation of calcium:sodium antiporter activity
protein localization to plasma membrane
membrane repolarization during cardiac muscle cell action potential
relaxation of cardiac muscle
regulation of calcium ion transmembrane transport
leukocyte migration
positive regulation of potassium ion transmembrane transporter activity
protein transport into plasma membrane raft
potassium ion import across plasma membrane
establishment or maintenance of transmembrane electrochemical gradient
transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
481
11931
Ensembl
ENSG00000143153
ENSMUSG00000026576
UniProt
P05026
P14094
RefSeq (mRNA)
NM_001677 NM_001001787
NM_009721
RefSeq (protein)
NP_001668
NP_033851
Location (UCSC)
Chr 1: 169.11 – 169.31 Mb
Chr 1: 164.26 – 164.29 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[5]
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000143153 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026576 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene. The protein encoded by this gene belongs to the family of Na+/K+ and...
to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM...
humans is encoded by the PXK gene. PXK binds to the Na⁺/K⁺-ATPase beta-1 (ATP1B1) and beta-3 (ATP1B3) subunits and modulates both Na⁺/K⁺-ATPase enzymatic...