ARFGAP1 information

ARFGAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O47, 3DWD
Identifiers
Aliases	ARFGAP1, ARF1GAP, HRIHFB2281, ADP ribosylation factor GTPase activating protein 1
External IDs	OMIM: 608377; MGI: 2183559; HomoloGene: 5517; GeneCards: ARFGAP1; OMA:ARFGAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,289,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,624,319 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; gastric mucosa; ; stromal cell of endometrium; ; right uterine tube; ; right lobe of thyroid gland; ; canal of the cervix; ; left lobe of thyroid gland; ; tibial nerve; ; body of pancreas; ; left uterine tube;
	Top expressed in
	fossa; ; internal carotid artery; ; condyle; ; external carotid artery; ; superior frontal gyrus; ; body of femur; ; lacrimal gland; ; yolk sac; ; calvaria; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; GTPase activator activity; protein binding;
Cellular component	cytoplasm; synapse; Golgi apparatus; cytosol; postsynaptic density; Golgi membrane;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; regulation of endocytosis; IRE1-mediated unfolded protein response; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein transport; vesicle-mediated transport; positive regulation of GTPase activity; regulation of ARF protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	55738
	228998
	ENSG00000101199
	ENSMUSG00000027575
	Q8N6T3
	Q9EPJ9
	NM_001281482; NM_001281483; NM_001281484; NM_018209; NM_175609
NM_001177706; NM_001177707; NM_001177708; NM_001177709; NM_001177710;
	NM_145760; NM_001363035; NM_001363036; NM_001363037; NM_001374670
	NP_001268411; NP_001268412; NP_001268413; NP_060679; NP_783202
NP_001171177; NP_001171178; NP_001171179; NP_001171180; NP_001171181;
	NP_665703; NP_001349964; NP_001349965; NP_001349966; NP_001361599
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene.^[5]^[6] Two transcript variants encoding different isoforms have been found for this gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027575 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Huber I, Rotman M, Pick E, Makler V, Rothem L, Cukierman E, Cassel D (February 2001). "Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1". Regulators and Effectors of Small GTPases Part E: GTPases Involved in Visicular Traffic. Methods in Enzymology. Vol. 329. pp. 307–16. doi:10.1016/S0076-6879(01)29092-2. ISBN 9780121822309. PMID 11210549.
^ "Entrez Gene: ARFGAP1 ADP-ribosylation factor GTPase activating protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027575 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11210549-5] Huber I, Rotman M, Pick E, Makler V, Rothem L, Cukierman E, Cassel D (February 2001). "Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1". Regulators and Effectors of Small GTPases Part E: GTPases Involved in Visicular Traffic. Methods in Enzymology. Vol. 329. pp. 307–16. doi:10.1016/S0076-6879(01)29092-2. ISBN 9780121822309. PMID 11210549.

[entrez-6] "Entrez Gene: ARFGAP1 ADP-ribosylation factor GTPase activating protein 1".

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