APBB1IP information

APBB1IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MWN, 3ZDL
Identifiers
Aliases	APBB1IP, amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein, INAG1, PREL1, RARP1, RIAM, amyloid beta precursor protein binding family B member 1 interacting protein
External IDs	OMIM: 609036; MGI: 1861354; HomoloGene: 32434; GeneCards: APBB1IP; OMA:APBB1IP - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	26,567,803 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	22,765,665 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; inferior ganglion of vagus nerve; ; trabecular bone; ; spleen; ; synovial joint; ; lactiferous duct; ; lymph node; ; superficial temporal artery;
	Top expressed in
	granulocyte; ; thymus; ; ankle joint; ; lactiferous gland; ; spleen; ; mesenteric lymph nodes; ; bone marrow; ; blood; ; molar; ; pharynx;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cell junction; cell projection; T cell receptor complex; cytoskeleton; membrane; focal adhesion; lamellipodium; cytosol; plasma membrane;
Biological process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; signal transduction; positive regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54518
	54519
	ENSG00000077420
	ENSMUSG00000026786
	Q7Z5R6
	Q8R5A3
	NM_019043
	NM_019456
	NP_061916
	NP_062329
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077420 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026786 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: amyloid beta (A4) precursor protein-binding".
^ Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi:10.1074/jbc.M308016200. PMID 14530287.
^ Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl:1721.1/83508. PMID 15469846.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077420 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026786 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: amyloid beta (A4) precursor protein-binding".

[pmid14530287-6] Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi:10.1074/jbc.M308016200. PMID 14530287.

[pmid15469846-7] Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl:1721.1/83508. PMID 15469846.

APBB1IP information

and 3 Related for: APBB1IP information

APBB1IP

RIAM

Pleckstrin homology domain