ANKS1A information

ANKS1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LMR, 2MYQ
Identifiers
Aliases	ANKS1A, ANKS1, ankyrin repeat and sterile alpha motif domain containing 1A
External IDs	OMIM: 608994; MGI: 2446180; HomoloGene: 9068; GeneCards: ANKS1A; OMA:ANKS1A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,091,406 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,281,749 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; seminal vesicula; ; endothelial cell; ; saphenous vein; ; paraflocculus of cerebellum; ; bronchial epithelial cell; ; amniotic fluid; ; mucosa of urinary bladder;
	Top expressed in
	interventricular septum; ; granulocyte; ; neural layer of retina; ; lip; ; utricle; ; vestibular membrane of cochlear duct; ; myocardium of ventricle; ; cerebellar cortex; ; cardiac muscles; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ephrin receptor binding;
Cellular component	neuron projection; cell projection; nucleoplasm; cytoplasm; cytosol;
Biological process	ephrin receptor signaling pathway; neuron remodeling; substrate-dependent cell migration; regulation of ephrin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23294
	224650
	ENSG00000064999
	ENSMUSG00000024219
	Q92625
	P59672
	NM_015245
	NM_001286040; NM_001286041; NM_181413; NM_001374802
	NP_056060
	NP_001272969; NP_001272970; NP_852078
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6.^[5]^[6]

It is ubiquitously expressed in many tissues and cell types.^[7] ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways.^[8] As a Src family kinase target, ODIN has been implicated in the development of cancer.^[9] The ANKS1A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024219 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ "Entrez Gene: ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A".
^ "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-10.^{[permanent dead link]}
^ Kristiansen TZ, Nielsen MM, Blagoev B, Pandey A, Mann M (August 2004). "Mouse embryonic fibroblasts derived from Odin deficient mice display a hyperproliiferative phenotype". DNA Research. 11 (4): 285–92. PMID 15500253.
^ Emaduddin M, Edelmann MJ, Kessler BM, Feller SM (2008-01-01). "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells". Cell Communication and Signaling. 6: 7. doi:10.1186/1478-811X-6-7. PMC 2584000. PMID 18844995.
^ Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM, Poulter NR, Sever PS, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS (June 2015). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–71. doi:10.1016/S0140-6736(14)61730-X. PMC 4608367. PMID 25748612.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064999 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024219 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

[entrez-6] "Entrez Gene: ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A".

[7] "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-10.^{[permanent dead link]}

[ReferenceA-8] Kristiansen TZ, Nielsen MM, Blagoev B, Pandey A, Mann M (August 2004). "Mouse embryonic fibroblasts derived from Odin deficient mice display a hyperproliiferative phenotype". DNA Research. 11 (4): 285–92. PMID 15500253.

[9] Emaduddin M, Edelmann MJ, Kessler BM, Feller SM (2008-01-01). "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells". Cell Communication and Signaling. 6: 7. doi:10.1186/1478-811X-6-7. PMC 2584000. PMID 18844995.

[ReferenceB-10] Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM, Poulter NR, Sever PS, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS (June 2015). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–71. doi:10.1016/S0140-6736(14)61730-X. PMC 4608367. PMID 25748612.

ANKS1A information

and 4 Related for: ANKS1A information

ANKS1A

XB130

Ankyrin repeat

Sterile alpha motif