AMFR information

AMFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EJS, 2LVN, 2LVO, 2LVP, 2LVQ, 2LXH, 2LXP, 3FSH, 3H8K, 3TIW, 4G3O, 4LAD
Identifiers
Aliases	AMFR, GP78, RNF45, autocrine motility factor receptor
External IDs	OMIM: 603243; MGI: 1345634; HomoloGene: 888; GeneCards: AMFR; OMA:AMFR - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,425,545 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,739,470 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right testis; ; left testis; ; gastrocnemius muscle; ; muscle of thigh; ; right adrenal cortex; ; Achilles tendon; ; ventricular zone; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	spermatocyte; ; Ileal epithelium; ; spermatid; ; secondary oocyte; ; granulocyte; ; decidua; ; ankle; ; dentate gyrus of hippocampal formation granule cell; ; triceps brachii muscle; ; digastric muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; chaperone binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; protein binding; ubiquitin-specific protease binding; transferase activity; identical protein binding; BAT3 complex binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; growth cone; integral component of endoplasmic reticulum membrane; neuronal cell body; dendrite; Derlin-1 retrotranslocation complex; perinuclear region of cytoplasm; nucleus; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; endoplasmic reticulum quality control compartment; protein-containing complex; ubiquitin ligase complex; cytosol;
Biological process	ERAD pathway; ubiquitin-dependent protein catabolic process; human ageing; protein polyubiquitination; endoplasmic reticulum unfolded protein response; protein K48-linked ubiquitination; protein complex oligomerization; protein ubiquitination; ubiquitin-dependent ERAD pathway; learning or memory; positive regulation of protein binding; signal transduction; protein autoubiquitination; protein folding; endoplasmic reticulum mannose trimming;
	Sources:Amigo / QuickGO
Orthologs
	267
	23802
	ENSG00000159461
	ENSMUSG00000031751
	Q9UKV5
	Q9R049
	NM_001144; NM_138958; NM_001323511; NM_001323512
	NM_011787
	NP_001135; NP_001310440; NP_001310441
	NP_035917
	Wikidata
View/Edit Human	View/Edit Mouse

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.^[5]^[6]

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159461 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem. 266 (20): 13442–8. doi:10.1016/S0021-9258(18)98859-9. PMID 1649192.
^ ^a ^b "Entrez Gene: AMFR autocrine motility factor receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159461 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031751 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1649192-5] Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem. 266 (20): 13442–8. doi:10.1016/S0021-9258(18)98859-9. PMID 1649192.

[entrez-6] "Entrez Gene: AMFR autocrine motility factor receptor".

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