Protein-coding gene in the species Homo sapiens
AKAP12 Identifiers Aliases AKAP12 , AKAP250, SSeCKS, A-kinase anchoring protein 12External IDs OMIM: 604698; MGI: 1932576; HomoloGene: 3740; GeneCards: AKAP12; OMA:AKAP12 - orthologs Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 151,239,967 bp[1] End 151,358,559 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 4,216,380 bp[2] End 4,309,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons lateral nuclear group of thalamus spinal ganglia trigeminal ganglion vena cava Pars compacta saphenous vein superior vestibular nucleus pericardium epithelium of colon
Top expressed in efferent ductule seminiferous tubule vas deferens stroma of bone marrow external carotid artery left lung lobe spermatid superior cervical ganglion endothelial cell of lymphatic vessel dermis
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
protein kinase A binding
protein binding
adenylate cyclase binding
Cellular component
plasma membrane
cell cortex
cytoskeleton
membrane
focal adhesion
cytoplasm
cytosol
Schaffer collateral - CA1 synapse
neuronal cell body
Biological process
protein targeting
G protein-coupled receptor signaling pathway
regulation of protein kinase C signaling
signal transduction
positive regulation of protein kinase A signaling
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of protein kinase A signaling
modulation of chemical synaptic transmission
response to lipopolysaccharide
hepatic stellate cell activation
negative regulation of vascular permeability
response to electrical stimulus
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of hepatic stellate cell migration
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of oligodendrocyte apoptotic process
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_005100 NM_144497 NM_001370346
RefSeq (protein) NP_005091 NP_653080 NP_001357275
Location (UCSC) Chr 6: 151.24 – 151.36 Mb Chr 10: 4.22 – 4.31 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000131016 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nauert JB, Klauck TM, Langeberg LK, Scott JD (Mar 1997). "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein". Curr. Biol . 7 (1): 52–62. Bibcode:1997CBio....7...52N. doi:10.1016/S0960-9822(06)00027-3 . PMID 9000000. S2CID 18843778.
^ "Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12".