Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta,[1] a North American funnel web spider. It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]
To identify new inhibitors, capsaicin receptor channels (TRPV1) were screened from a venom library for activity against these channels. In result, the robust inhibitory activity was found in the venom. Venom fractionation utilizing a reversed phase HPLC [2] which led to the purification of the two acylpolyamine toxins, AG489 and AG505. Both of these inhibit the TRPV1 channels [3] from the extracellular membrane side. From the pore blocking mechanism, the pore mutations that change toxic affinity were identified. As a result, the four mutants decreased toxic affinity and several mutants increased it. Therefore, this was consistent with the scanned TM5-TM6 linker region [4] being the outer vestibule of the channels and further confirming that AG489 is a pore blocker.
^Herold EE, Yaksh TL (September 1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.
^ abKitaguchi T, Swartz KJ (November 2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.
^Kaneko Y, Szallasi A (May 2014). "Transient receptor potential (TRP) channels: a clinical perspective". British Journal of Pharmacology. 171 (10): 2474–507. doi:10.1111/bph.12414. PMC 4008995. PMID 24102319.
^Winter Z, Buhala A, Ötvös F, Jósvay K, Vizler C, Dombi G, et al. (June 2013). "Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data". Molecular Pain. 9: 30. doi:10.1186/1744-8069-9-30. PMC 3707783. PMID 23800232.
AG489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta, a North American funnel web spider. It inhibits the ligand gated...
Year 489 (CDLXXXIX) was a common year starting on Sunday (link will display the full calendar) of the Julian calendar. At the time, it was known as the...
of polyamines which are attached to an aromatic moiety (see for example AG489). Mu-agatoxins are C-terminally amidated peptides, consisting of 35-37 amino...
Deutsche Bank AG (German pronunciation: [ˈdɔʏtʃə ˈbaŋk ʔaːˈɡeː] ) is a German multinational investment bank and financial services company headquartered...
active duty at Daimler-Benz AG November 1982) · pp. 9 · 22 Hans Joachim Foerster · Automatische Fahrzeuggetriebe · p. 489 · Berlin and Heidelberg 1991...
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals...
Dresdner Bank AG was a German bank, founded in 1872 in Dresden, then headquartered in Berlin from 1884 to 1945 and in Frankfurt from 1963 onwards after...
September 2017. "1st AG New Delhi 1951". OCA. Archived from the original on 11 September 2018. Retrieved 22 July 2010. "2nd AG Manila 1954". OCA. Archived...
Presley 1985, p. 299. Guralnick & Jorgensen 1999, p. 310. Goldman 1981, p. 489. Guralnick, Peter (2000). Careless love : the unmaking of Elvis Presley (Book)...
Corporation (also known as Bayer USA) is the American subsidiary of Bayer AG. Its main offices are located in Whippany, New Jersey. In addition it has...
consumers". Proceedings of the Human Factors Society Annual Meeting. 34 (5): 489–493. doi:10.1177/154193129003400512. Armson, Morandir (June 2011). "The transitory...
2017. Volkswagen AG 2012, p. 102. Volkswagen AG 2012a, p. 120. "vwagfy2012". Archived from the original on 4 October 2013. Volkswagen AG 2012a, p. 121....
covalent character of the bonds in AgCl and AgBr reduces the bond length and hence the apparent ionic radius of Ag+, an effect which is not present in...
electrical accessories. Büttner's company, Bayerische Elektrozubehör AG, was granted patent DE 489 003 in 1930 for a Stecker mit Erdungseinrichtung ('plug with...
1032 Broom yellow Deutsche Bundespost since 1980, since 1998 Deutsche Post AG RAL 1033 Dahlia yellow RAL 1034 Pastel yellow RAL 1035 Pearl beige RAL 1036...
in the genetic code". Comparative Biochemistry and Physiology. 106 (2): 489–94. doi:10.1016/0305-0491(93)90122-l. PMID 8281749. Archived from the original...
"Nudging out support for a carbon tax". Nature Climate Change. 9 (6): 484–489. Bibcode:2019NatCC...9..484H. doi:10.1038/s41558-019-0474-0. S2CID 182663891...
vague. AG van Gerven, in Marshall (No 2) (1993) C-271/91, [1993] ECR I-4367 (Opinion), AG Jacobs, in Vaneetveld, C-316/93, [1994] ECR I-763, AG Lenz, in...
(drei) 664 mobilkom Austria AG (Mobilkom, A1) 676 T-Mobile Austria GmbH (T-Mobile, formerly max) 680 mobilkom Austria AG (Bob) 677 11 HoT (T-Mobile, formerly...