ADAMTS9 information

ADAMTS9
Identifiers
Aliases	ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
External IDs	OMIM: 605421; MGI: 1916320; HomoloGene: 18821; GeneCards: ADAMTS9; OMA:ADAMTS9 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	64,688,000 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	92,920,473 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; endometrium; ; parietal pleura; ; body of uterus; ; right ventricle; ; pericardium; ; upper lobe of left lung; ; left uterine tube; ; left coronary artery; ; ascending aorta;
	Top expressed in
	renal corpuscle; ; gastrula; ; molar; ; external carotid artery; ; cumulus cell; ; vas deferens; ; left lung lobe; ; dermis; ; Gonadal ridge; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; metalloendopeptidase activity; endopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	extracellular region; cell surface; extracellular space; extracellular matrix; endoplasmic reticulum; intracellular membrane-bounded organelle; collagen-containing extracellular matrix;
Biological process	multicellular organism development; protein transport; regulation of developmental pigmentation; vesicle-mediated transport; positive regulation of melanocyte differentiation; proteolysis; glycoprotein catabolic process; heart valve morphogenesis; ventricular cardiac muscle tissue development; negative regulation of endothelial cell migration; extracellular matrix organization; aorta morphogenesis; endothelial cell-matrix adhesion; negative regulation of sprouting angiogenesis; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	56999
	101401
	ENSG00000163638
	ENSMUSG00000030022
	Q9P2N4
	n/a
	NM_182920; NM_001318781; NM_020249; NM_182921
	NM_175314
	NP_001305710; NP_891550
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.^[5]^[6]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163638 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark ME, Kelner GS, Turbeville LA, Boyer A, Arden KC, Maki RA (Sep 2000). "ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family". Genomics. 67 (3): 343–50. doi:10.1006/geno.2000.6246. PMID 10936055.
^ ^a ^b "Entrez Gene: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163638 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10936055-5] Clark ME, Kelner GS, Turbeville LA, Boyer A, Arden KC, Maki RA (Sep 2000). "ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family". Genomics. 67 (3): 343–50. doi:10.1006/geno.2000.6246. PMID 10936055.

[entrez-6] "Entrez Gene: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9".

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ADAMTS

Thrombospondin