ADAMTS7 information

A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15.^[1] It is ubiquitously expressed in many tissues and cell types.^[2] This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP).^[3] ADAMTS7 has been associated with cancer and arthritis in multiple tissue types.^[4]^[5] The ADAMTS7 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.^[6]

^ "ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-10-06.
^ "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-06.
^ Liu, Chuan-Ju; Kong, Wei; Ilalov, Kiril; Yu, Shuang; Xu, Ke; Prazak, Lisa; Fajardo, Marc; Sehgal, Bantoo; Di Cesare, Paul E. (2006-05-01). "ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein". FASEB Journal. 20 (7): 988–990. doi:10.1096/fj.05-3877fje. ISSN 1530-6860. PMC 1483927. PMID 16585064.
^ Yao, Song; Johnson, Christopher; Hu, Qiang; Yan, Li; Liu, Biao; Ambrosone, Christine B.; Wang, Jianmin; Liu, Song (2016-05-26). "Differences in somatic mutation landscape of hepatocellular carcinoma in Asian American and European American populations". Oncotarget. 7 (26): 40491–40499. doi:10.18632/oncotarget.9636. ISSN 1949-2553. PMC 5130022. PMID 27246981.
^ Zhang, Yuying; Lin, Jiqiang; Wei, Fanhua (2015-01-01). "The Function and Roles of ADAMTS-7 in Inflammatory Diseases". Mediators of Inflammation. 2015: 801546. doi:10.1155/2015/801546. ISSN 1466-1861. PMC 4677222. PMID 26696755.
^ Mega, Jessica L.; Stitziel, Nathan O.; Smith, J. Gustav; Chasman, Daniel I.; Caulfield, Mark J.; Devlin, James J.; Nordio, Francesco; Hyde, Craig L.; Cannon, Christopher P. (2015-06-06). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–2271. doi:10.1016/S0140-6736(14)61730-X. ISSN 1474-547X. PMC 4608367. PMID 25748612.

[:0-1] "ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-10-06.

[2] "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-06.

[Liu_988–990-3] Liu, Chuan-Ju; Kong, Wei; Ilalov, Kiril; Yu, Shuang; Xu, Ke; Prazak, Lisa; Fajardo, Marc; Sehgal, Bantoo; Di Cesare, Paul E. (2006-05-01). "ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein". FASEB Journal. 20 (7): 988–990. doi:10.1096/fj.05-3877fje. ISSN 1530-6860. PMC 1483927. PMID 16585064.

[Yao_40491–40499-4] Yao, Song; Johnson, Christopher; Hu, Qiang; Yan, Li; Liu, Biao; Ambrosone, Christine B.; Wang, Jianmin; Liu, Song (2016-05-26). "Differences in somatic mutation landscape of hepatocellular carcinoma in Asian American and European American populations". Oncotarget. 7 (26): 40491–40499. doi:10.18632/oncotarget.9636. ISSN 1949-2553. PMC 5130022. PMID 27246981.

[Zhang_801546-5] Zhang, Yuying; Lin, Jiqiang; Wei, Fanhua (2015-01-01). "The Function and Roles of ADAMTS-7 in Inflammatory Diseases". Mediators of Inflammation. 2015: 801546. doi:10.1155/2015/801546. ISSN 1466-1861. PMC 4677222. PMID 26696755.

[Mega_2264–2271-6] Mega, Jessica L.; Stitziel, Nathan O.; Smith, J. Gustav; Chasman, Daniel I.; Caulfield, Mark J.; Devlin, James J.; Nordio, Francesco; Hyde, Craig L.; Cannon, Christopher P. (2015-06-06). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–2271. doi:10.1016/S0140-6736(14)61730-X. ISSN 1474-547X. PMC 4608367. PMID 25748612.

ADAMTS7 information

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Thrombospondin