The 2016 season was the Arizona Cardinals' 97th in the National Football League, their 118th overall, their 29th in Arizona, their 11th at University of Phoenix Stadium and their fourth under head coach Bruce Arians.
In free agency, they signed veteran defensive back Tyvon Branch and veteran lineman Evan Mathis, while re-signing several key players. They traded for Chandler Jones from the New England Patriots, sending Jonathan Cooper and a late second-round pick to New England.
The Cardinals came into the 2016 season with expectations of improving on their 2015 campaign and reaching the Super Bowl. However, after a 1–3 start, they suffered injuries to quarterback Carson Palmer and most of the offensive line. On October 23, the Cardinals and the Seattle Seahawks played out a 6–6 tie; this was the Cardinals' first tie since 1986 when they were the St. Louis Cardinals. It was also the lowest-scoring NFL tie since overtime was introduced in 1974. The Cardinals were eliminated from playoff contention in Week 15 after a loss to the New Orleans Saints. Despite winning their final two games, the Cardinals ended the season with a losing record at 7–8–1. Because the Chicago Cubs won the 2016 World Series, their first title in 108 years, the Cardinals also finished the season with the longest active championship drought in the four major American professional sports, with their last championship in 1947 as the Chicago Cardinals.
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