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Abū Yaʿqūb Yūsuf al-Hamadānī, best simply known as Yusuf Hamadani (born 1048 or 1049 / 440 AH - died 1140 / 535 AH), was a Persian Sufi of the Middle Ages. He was the first of the group of Central Asian Sufi teachers known simply as Khwajagan (the Masters) of the Naqshbandi order. His shrine is at Merv, Turkmenistan.
Khwaja Yusuf was a Persian, and, as his nisba suggests, came from Hamadan.