Pleiotrophin information

PTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N6F
Identifiers
Aliases	PTN, HARP, HBGF8, HBNF, NEGF1, HB-GAM, HBBM, HBGF-8, HBNF-1, OSF-1, pleiotrophin
External IDs	OMIM: 162095; MGI: 97804; HomoloGene: 2117; GeneCards: PTN; OMA:PTN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	137,343,774 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	36,787,155 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; trigeminal ganglion; ; optic nerve; ; ventral tegmental area; ; amygdala; ; periodontal fiber; ; corpus callosum; ; nucleus accumbens; ; pons;
	Top expressed in
	genital tubercle; ; optic nerve; ; efferent ductule; ; vestibular sensory epithelium; ; median eminence; ; Gonadal ridge; ; gastrula; ; vas deferens; ; abdominal wall; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glycosaminoglycan binding; protein phosphatase inhibitor activity; heparan sulfate binding; heparin binding; growth factor activity; chondroitin sulfate binding; protein kinase binding; chondroitin sulfate proteoglycan binding; vascular endothelial growth factor binding; proteoglycan binding;
Cellular component	cytoplasm; membrane; neuromuscular junction; basement membrane; cell surface; extracellular region; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular space; protein-containing complex; presynapse; postsynapse;
Biological process	positive regulation of hepatocyte proliferation; bone mineralization; response to estradiol; ossification; lung development; thalamus development; response to kainic acid; estrous cycle; cellular response to UV; negative regulation of glial cell proliferation; response to ciliary neurotrophic factor; response to progesterone; response to nerve growth factor; cellular response to organic cyclic compound; hindbrain development; cellular response to platelet-derived growth factor stimulus; cellular response to vitamin D; learning; response to activity; negative regulation of membrane potential; cerebellum development; nervous system development; positive regulation of skeletal muscle acetylcholine-gated channel clustering; rod bipolar cell differentiation; heart development; transmembrane receptor protein tyrosine phosphatase signaling pathway; brain development; negative regulation of cell migration; retina development in camera-type eye; negative regulation of neuromuscular junction development; spinal cord development; regulation of cell shape; positive regulation of neuron projection development; positive regulation of apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of angiogenesis; retinal rod cell differentiation; endothelial cell differentiation; liver development; negative regulation of mesenchymal cell proliferation; cellular response to hypoxia; positive regulation of cell division; long-term potentiation; positive regulation of cell-substrate adhesion; positive regulation of cell population proliferation; regulation of signaling receptor activity; negative regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	5764
	19242
	ENSG00000105894
	ENSMUSG00000029838
	P21246
	P63089
	NM_002825; NM_001321386; NM_001321387
	NM_008973
	NP_001308315; NP_001308316; NP_002816
	NP_032999
	Wikidata
View/Edit Human	View/Edit Mouse

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene.^[5] Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105894 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PTN pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105894 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PTN pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)".

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