An antibody with a circled region depicting where the paratope is found. 1. Antigen-binding fragment (Fab) 2. Antibody crystallizable region (Fc) 3. Heavy chains 4. Light chains 5. Variable region of the antibody. The paratope is the key-shaped section that makes direct contact with the antigen.[1] 6. Hinge regions
In immunology, a paratope, also known as an antigen-binding site, is the part of an antibody which recognizes and binds to an antigen.[1][2] It is a small region at the tip of the antibody's antigen-binding fragment and contains parts of the antibody's heavy and light chains.[1][2] Each paratope is made up of six complementarity-determining regions - three from each of the light and heavy chains - that extend from a fold of anti-parallel beta sheets.[2] Each arm of the Y-shaped antibody has an identical paratope at the end.[2]
Paratopes make up the parts of the B-cell receptor that bind to and make contact with the epitope of an antigen.[2] All the B-cell receptors on any one individual B cell have identical paratopes.[2] The uniqueness of a paratope allows it to bind to only one epitope with high affinity and as a result, each B cell can only respond to one epitope. The paratopes on B-cell receptors binding to their specific epitope is a critical step in the adaptive immune response.
^ abcLefranc MP (2013). "Paratope". In Dubitzky W, Wolkenhauer O, Cho KH, Yokota H (eds.). Encyclopedia of Systems Biology. New York, NY: Springer. pp. 1632–1633. doi:10.1007/978-1-4419-9863-7_673. ISBN 978-1-4419-9863-7.
^ abcdefPunt J, Stranford SA, Jones PP, Owen JA (2019). Kuby immunology (Eighth ed.). New York. ISBN 978-1-4641-8978-4. OCLC 1002672752.{{cite book}}: CS1 maint: location missing publisher (link)
In immunology, a paratope, also known as an antigen-binding site, is the part of an antibody which recognizes and binds to an antigen. It is a small region...
T cells. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from...
molecule, where epitope means an antigenic determinant. He also defined the "paratope" to be that part of an antibody variable region that binds to an antigen...
receptor. Such segments are called epitopes. Likewise, it is only the paratope of the receptor that comes in contact with the epitope. Proteins are composed...
are created and released by plasma B cells. Each IgG antibody has two paratopes. Antibodies are major components of humoral immunity. IgG is the main...
antigen-specific antibody. Each tip of the "Y" of an antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing...
domain complexed with snake venom bitiscetin 2adf: Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the...
receptors (TCRs). The molecular region which binds to the epitope is the paratope. On surfaces of helper T cells are CD4 receptors, as well as TCRs. When...
15–22 amino acids) of the antibody molecule; this region is known as the paratope. In the immune system, membrane-bound antibodies are the B-cell receptor...
antigen can be characterized by its ability to bind to an antibody's paratopes. Different antibodies have the potential to discriminate among specific...
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between the complex structures of the epitope of antigenic determinant and paratope of antigen-binding site of an antibody. Participating non-covalent interactions...
immunoglobulin E (IgE) becomes bound to mast cells and basophils, and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other...
antibody. Such segments are called epitopes. Likewise, it is only the paratope of the antibody that comes in contact with the epitope. Proteins are composed...
between rigidity and specificity. This correlation extends far beyond the paratope of the antibodies Enzyme specificity refers to the interactions between...
of the labelled cross-linkers and the bound peptides (both epitope and paratope are determined in one experiment). The key advantage of this technique...
Isotype Idiotype Functions Antibody opsonization Neutralisation Regions Paratope Complementarity-determining region (CDRs) Hypervariable region Framework...
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