Mitotic recombination is a type of genetic recombination that may occur in somatic cells during their preparation for mitosis in both sexual and asexual organisms. In asexual organisms, the study of mitotic recombination is one way to understand genetic linkage because it is the only source of recombination within an individual.[1] Additionally, mitotic recombination can result in the expression of recessive alleles in an otherwise heterozygous individual. This expression has important implications for the study of tumorigenesis and lethal recessive alleles.[1][2]
Mitotic homologous recombination occurs mainly between sister chromatids subsequent to replication (but prior to cell division). Inter-sister homologous recombination is ordinarily genetically silent. During mitosis the incidence of recombination between non-sister homologous chromatids is only about 1% of that between sister chromatids.[3]
^ abHartl, Daniel L. and Maryellen Ruvolo (2012). Genetics: Analysis of Genetics and Genomes. Burlington: Jones & Bartlett.
^Tischfield, Jay A. (November 1997). "Loss of Heterozygosity, or: How I learned to Stop Worrying and Love Mitotic Recombination". American Journal of Human Genetics. 61 (5): 995–999. doi:10.1086/301617. PMC 1716040. PMID 9345110.
Mitoticrecombination is a type of genetic recombination that may occur in somatic cells during their preparation for mitosis in both sexual and asexual...
repair recombinogenic DNA damages primarily by recombination between homologous chromosomes. Mitotic cells irradiated in the G2 phase repair such damages...
other so that recombination characteristically occurs between non-sister homologues. In both meiotic and mitotic cells, recombination between homologous...
adaptive function of meiosis and recombination. Mutations defective in genes essential for meiotic and mitoticrecombination in S. cerevisiae cause increased...
"Meiotic versus mitoticrecombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are...
detect DNA damage or when incorrectly attached mitotic spindles do not function properly. Mitoticrecombination is primarily a result of DNA repair processes...
like point mutations/deletions, nondisjunction, and homologous mitoticrecombination might theoretically cause this loss of heterozygosity, nondisjunction...
gene has localized cis-acting mitoticrecombination stimulating activity. This DNA fragment contains a mitoticrecombination hotspot, referred to as HOT1...
needed] Recombination hotspots are DNA sequences that increase local recombination. The HOT1 sequence in yeast is one of the most well studied mitotic recombination...
Busso, C; Castro-Prado, MA (March 2004). "Cremophor EL stimulates mitoticrecombination in uvsH//uvsH diploid strain of Aspergillus nidulans". Anais da...
"Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint". PLOS Genet. 4 (2): e31...
mouse brain, while it was about 1 day in mouse liver. EMS induces mitoticrecombination in Saccharomyces cerevisiae. It was suggested that EMS damage to...
functioning TSG allele, the original published mechanism of RB1 LOH was mitoticrecombination/gene conversion/copy-neutral LOH, not deletion. There is a critical...
PMID 20195513. Esposito MS (September 1978). "Evidence that spontaneous mitoticrecombination occurs at the two-strand stage". Proceedings of the National Academy...
sensitivity of U. maydis to DNA damaging agents is increased. Also mitoticrecombination becomes deficient, mutation frequency increases and meiosis fails...
has been hypothesized that this is the result of a combination of mitoticrecombination and natural selection within the skin. List of cutaneous conditions...
also been observed more frequently in B51(+) Behçet's disease. Mitoticrecombination in the budding yeast Saccharomyces cerevisiae is primarily a result...
together with the short arm of chromosome 9 (9p), likely due to mitoticrecombination causing copy-neutral loss of heterozygosity. While the JAK2 V617F...
active in homologous recombination. Cells defective in the WRN gene have a 23-fold reduction in spontaneous mitoticrecombination, with especial deficiency...
fully realized for plant chromosomes in 1990. During both meiotic and mitotic prophase, giemsa staining can be applied to cells to elicit G-banding in...
induced by these agents. This repair mechanism likely involves mitoticrecombination between homologous DNA regions. Rotifers fall prey to many animals...
protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate...
gets none. This is known as a chromatin bridge or an anaphase bridge. Mitotic nondisjunction results in somatic mosaicism, since only daughter cells...
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