Metekel Zone is located in Benishangul-Gumuz of Ethiopia. It is bordered on the south and southwest by Kamashi, on the west by Sudan, and on the north and east by the Amhara region. The Abay River defines the Zone's boundaries with Kamashi, while the Dinder River defines part of its boundary with the Amhara region.
The administrative center of Metekel Zone is Gilgil Beles; other towns include Manbuk. The highest point is Mount Belaya (3,131 meters), which is part of the Dangur range.
MIDROC Gold reported in 2009 that it was exploring the Zone for gold deposits.