An immunogen is any substance that generates B-cell (humoral/antibody) and/or T-cell (cellular) adaptive immune responses upon exposure to a host organism.[1][2] Immunogens that generate antibodies are called antigens ("antibody-generating").[2] Immunogens that generate antibodies are directly bound by host antibodies and lead to the selective expansion of antigen-specific B-cells. Immunogens that generate T-cells are indirectly bound by host T-cells after processing and presentation by host antigen-presenting cells.
An immunogen can be defined as a complete antigen which is composed of the macromolecular carrier and epitopes (determinants) that can induce immune response.
An explicit example is a hapten. Haptens are low-molecular-weight compounds that may be bound by antibodies, but cannot elicit an immune response. Consequently, the haptens themselves are nonimmunogenic and they cannot evoke an immune response until they bind with a larger carrier immunogenic molecule. The hapten-carrier complex, unlike free hapten, can act as an immunogen and can induce an immune response.[3]
Until 1959, the terms immunogen and antigen were not distinguished.[4]
^
"im·mu·no·gen", Merriam-Webster Collegiate Dictionary (11th ed.), Springfield, Massachusetts, USA: Merriam-Webster, Inc., 2003, a substance that produces an immune response
^ ab
"Immunogen". immunopaedia.org.za. 4 March 2015. Archived from the original on 2021-10-21. Retrieved 2021-10-21. A substance capable of eliciting a immune response. All immunogens are antigens, but some antigen are not immunogens (e.g. haptens)
^Abbas A.K.; Lichtman A.H.; Pillai S. (2012). Cellular and Molecular Immunology. 7th edition. Elsevier, Ed. Gruliow R. pp. 101–103, 483.
^Medical Dictionary, Merriam-Webster. "Immunogen". Archived from the original on 2014-01-01. Retrieved 2013-12-31.
ImmunoGen, Inc. was a biotechnology company focused on the development of antibody-drug conjugate (ADC) therapeutics for the treatment of cancer. ImmunoGen...
An immunogen is any substance that generates B-cell (humoral/antibody) and/or T-cell (cellular) adaptive immune responses upon exposure to a host organism...
antibody medicines. In November 2023, AbbVie announced it would be buying ImmunoGen for $10.1 billion, aiming to expedite its entry into the ovarian cancer...
according to the WHO. DM1 and its attachment via these linkers result from ImmunoGen Inc research. An example is: Trastuzumab emtansine (T-DM1), an anti-HER2/neu...
molecular form. If its molecular form is changed, a tolerogen can become an immunogen. Immunoglobulin-binding protein – Proteins such as protein A, protein...
based on an antibody layer that interacts selectively with a particular immunogen and reports about its content in a specimen. In the static mode of operation...
response, it is an 'immunogenic antigen', which is referred to as an immunogen. Many lipids and nucleic acids are relatively small molecules and/or have...
(2018-03-08). "Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines". Cell. 172 (6): 1319–1334. doi:10...
interest) are sometimes constructed to express more than one immunogen, or to express an immunogen and an immunostimulatory protein. Because the plasmid –...
Mycobacteroides immunogenum (formerly Mycobacterium immunogenum) is a species of bacteria from the phylum Actinomycetota, belonging to the genus Mycobacteroides...
Biotechnology News. ImmunoGen reports encouraging clinical data of IMGN901. News-medical.net. Retrieved on 2010-11-20. "ImmunoGen receives FDA orphan...
immune system becomes fortified against an infectious agent (known as the immunogen). When this system is exposed to molecules that are foreign to the body...
and preservatives) very little of which is the active ingredient, the immunogen. A single dose may have merely nanograms of virus particles, or micrograms...
she co-discovered the vault (organelle). Subsequently, she worked at ImmunoGen Inc. where she worked on staining and photographing different cancer cells...
and preservatives) very little of which is the active ingredient, the immunogen. A single dose may have merely nanograms of virus particles, or micrograms...
University Press. ISBN 9780691028323. Retrieved May 4, 2017. Remune (HIV-1 Immunogen, Salk vaccine) Archived March 21, 2009, at the Wayback Machine AIDSmeds...
investments of the 1970s were Biogen, Artificial Intelligence Software, Immunogen and Digital Research. Jacqui Morby, one of the first women to become a...
generic sense, vaccination works by priming the immune system with an 'immunogen'. Stimulating immune response, by use of an infectious agent, is known...
Ansamitocin Mertansine / emtansine (DM1) Ravtansine / soravtansine (DM4) ImmunoGen, developer of maytansinoid based drugs National Cancer Institute: Definition...
institute also incorporates the: Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery Center for Metabolomics Center for Viral Systems Biology[citation...