Representation of biological membrane depolarization
In membrane biology, the Hodgkin cycle is a key component of membrane physiology that describes bioelectrical impulses, especially prevalent in neural and muscle tissues. It was identified by British physiologist and biophysicist Sir Alan Lloyd Hodgkin.[1]
The Hodgkin cycle represents a positive feedback loop in which an initial membrane depolarization leads to uncontrolled deflection of the membrane potential to near VNa. The initial depolarization must reach or surpass a certain threshold in order to activate voltage-gated Na+ channels. The opening of Na+ channels allows Na+ inflow, which, in turn, further depolarizes the membrane. Additional depolarization activates additional Na+ channels. This cycle leads to a very rapid rise in Na+ conductance (gNa), which moves the membrane potential close to VNa. The cycle is broken when the membrane potential reaches to the sodium equilibrium potential and potassium channels open to re-polarize the membrane potential. This positive feedback loop means that the closer these voltage-gated Na+ channels are to each other, the lower the threshold of activation.[1]
^ abFinger, Stanley; Piccolino, Marco (8 September 2011). The Shocking History of Electric Fishes. OUP USA.
In membrane biology, the Hodgkincycle is a key component of membrane physiology that describes bioelectrical impulses, especially prevalent in neural...
Sir Alan Lloyd Hodgkin OM KBE FRS (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist who shared the 1963 Nobel Prize in...
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cellular physiology. Membrane bioelectrical impulses are described by the Hodgkincycle. Membrane biophysics is the study of biological membrane structure and...
potential, which in turn causes more opening of channels, and so on (Hodgkincycle). So a slight initial leakage results in an explosion of sodium leakage...
potential. An action potential occurs when this positive feedback cycle (Hodgkincycle) proceeds explosively. The time and amplitude trajectory of the action...
incarcerated. As a final twist, Hodgkins is dubbed the "last victim [of the] Curse of the Ponape Figurine." The fourth story in the cycle chronicles the events...
Alan Lloyd Hodgkin 1914–1998 United Kingdom Nobel Prize in Physiology or Medicine - 1963. Hodgkin–Huxley model, GHK flux equation, Hodgkincycle Oleh Hornykiewicz...
oscillations are modelled. Some examples include: Aerodynamic limit-cycle oscillations The Hodgkin–Huxley model for action potentials in neurons. The Sel'kov model...
Helmholtz Heterotrimeric G protein Hill's muscle model Hille equation HodgkincycleHodgkin–Huxley model Homeoviscous adaptation Homologous desensitization...
BEACOPP is a chemotherapy regimen for treatment of Hodgkin lymphoma developed by the German Hodgkin Study Group used for patients in Stages > II or early...
Nanako SOS, Chō Kōsoku Galvion), dies at age 70 from bile duct cancer. Hodgkins, Crystalyn (November 17, 2023). "Polygon Pictures' Bloody Escape Anime...
differentiation is controlled by the cell cycle". Immunity. 9 (2): 229–37. doi:10.1016/S1074-7613(00)80605-6. PMID 9729043. Hodgkin PD, Lee JH, Lyons AB (July 1996)...
and it was the basis of Hodgkin and Huxley's pioneering experiments on the properties of the action potential. Alan Hodgkin realized that, to understand...
medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given...
depolarised by slowly rising current (ramp depolarisation) in vitro. The Hodgkin–Huxley model also shows accommodation. Sudden depolarisation of a nerve...
ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, replacing the older MOPP protocol. It consists of concurrent treatment...
treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not...
other medications, to treat a number of types of cancer. This includes Hodgkin's lymphoma, non-small-cell lung cancer, bladder cancer, brain cancer, melanoma...
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