In immunology, cryptic self epitopes are a source of autoimmunity.
Self epitopes, which are found in high concentration on the surface of antigen-presenting cells (APCs) in association with its major histocompatibility complex (MHC) are known as dominant epitopes. These are stimulants of negative selection mechanisms to remove potentially self destructing autoreactive T cells. Their "self" antigens are displayed to a developing T-cell and signal those "self-reactive" T-cells to die via programmed cell death (apoptosis) and thereby deletion from the T cell repertoire, preventing autoimmunity.
However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete autoreactive T-cells which will then join the peripheral adult T cell repertoire. This causes autoimmunity in the body.
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In immunology, crypticselfepitopes are a source of autoimmunity. Selfepitopes, which are found in high concentration on the surface of antigen-presenting...
epitopes. In contrast to molecular mimicry, the other epitopes need not be structurally similar to the primary one. Epitope modification or Cryptic epitope...
by selfepitopes released secondary to pathogen-specific T cell-mediated bystander damage. T cell responses to progressively less dominant epitopes are...
transcripts provides the structural basis for expression of untolerized epitopes". The Journal of Allergy and Clinical Immunology. 114 (6): 1463–1470. doi:10...
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Krupovic M, Daly RA, Borges AL, Nayfach S, Schulz F, et al. (November 2019). "Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth's...
understood to be a complex event involving epitope spreading to multiple tissue-specific antigens and crypticepitopes. Thus, at any given stage of disease...
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