Borna disease, also known as sad horse disease,[1] is an infectious neurological syndrome[2] of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2). BoDV-1/2 are neurotropic viruses of the species Mammalian 1 orthobornavirus, and members of the Bornaviridae family within the Mononegavirales order.
Borna disease is a severe neurological illness that predominantly affects horses and sheep, but it has been observed in a wide range of mammals. The disease is characterised by ataxia and abnormal depressive behaviour, frequently culminating in death. There have been rare cases of human fatalities associated with encephalitis caused by Borna disease virus infection.[3] Additionally, correlative evidence exists linking BoDV-1/2 infection with neuropsychiatric disorders such as bipolar disorder in humans.[4]
^Colman AM (2009-01-01), "Sad horse disease", A Dictionary of Psychology, Oxford University Press, doi:10.1093/acref/9780199534067.001.0001, ISBN 978-0-19-953406-7, retrieved 2020-01-16
^Ackermann A, Staeheli P, Schneider U (August 2007). "Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity". Journal of Virology. 81 (15): 7933–7940. doi:10.1128/JVI.00334-07. PMC 1951315. PMID 17522214.
^Niller HH, Angstwurm K, Rubbenstroth D, Schlottau K, Ebinger A, Giese S, et al. (April 2020). "Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation". The Lancet. Infectious Diseases. 20 (4): 467–477. doi:10.1016/s1473-3099(19)30546-8. PMID 31924550. S2CID 210149895.
^Cite error: The named reference Bode_1990 was invoked but never defined (see the help page).
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humans serve as natural hosts. Diseases associated with bornaviruses include Bornadisease, a fatal neurologic disease of mammals restricted to central...
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nucleic acid type, mode of replication, host organisms, and the type of disease they cause. The formal taxonomic classification of viruses is the responsibility...
viral genomic RNA into and out of the nucleus: influenza, Thogoto and Bornadisease viruses". Virus Res. 95 (1–2): 3–12. doi:10.1016/S0168-1702(03)00159-X...
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the clinical core of an international investigation of the role of Bornadisease virus in human mental illness and participates as a key investigator...
varicella-zoster, rubella, herpes simplex, maternal genital infections, Bornadisease virus, and Toxoplasma gondii have been correlated with the later development...
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University School of Medicine, where she studied the virus associated with Bornadisease. She joined the faculty of Colorado State University in 1990 and became...
Koong FJ, Liu HC, Shaw CK, et al. (January 1999). "High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health...
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