Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Acromelic acid A (ACRO A) is a toxic compound that is part of a group known as kainoids, characterized by a structure bearing a pyrrolidine dicarboxylic acid, represented by kainic acid.[4] Acromelic acid A has the molecular formula C13H14N2O7. It has been isolated from a Japanese poisonous mushroom, Clitocybe acromelalga.[5] Acromelic acid is responsible for the poisonous aspects of the mushroom because of its potent neuroexcitatory and neurotoxic properties.[6] Ingestion of the Clitocybe acromelalga, causes allodynia which can continue for over a month.[7] The systemic administration of acromelic acid A in rats results in selective loss of interneurons in the lower spinal cord, without causing neuronal damage in the hippocampus and other regions.[8]
^"Acromelic acid A". pubchem. National Center for Biotechnology Information. Retrieved 4 March 2024.
^ ab"acromelic acid A". Chemspider. Royal society of chemistry. Retrieved 4 March 2024.
^"acromelic acid A". chemicalbook. Retrieved 4 March 2024.
^Furuta, Kyoji; Wang, Guang Xing; Minami, Toshiaki; Nishizawa, Mikio; Ito, Seiji; Suzuki, Masaaki (2004-03-17). "A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies". Tetrahedron Letters. 45 (20): 3933–3936. doi:10.1016/j.tetlet.2004.03.098. ISSN 0040-4039.
^Shinozaki, H.; Ishida, M.; Gotoh, Y.; Kwak, S. (1990), Lubec, Gert; Rosenthal, Gerald A. (eds.), "Acromelic acid as a tool for the study of specific neurone damages", Amino Acids: Chemistry, Biology and Medicine, Dordrecht: Springer Netherlands, pp. 281–293, doi:10.1007/978-94-011-2262-7_32, ISBN 978-94-011-2262-7, retrieved 2024-03-04
^Yin, Xia; Yang, An-An; Gao, Jin-Ming (2019-05-08). "Mushroom Toxins: Chemistry and Toxicology". Journal of Agricultural and Food Chemistry. 67 (18): 5053–5071. doi:10.1021/acs.jafc.9b00414. ISSN 1520-5118. PMID 30986058. S2CID 116862463.
^Cite error: The named reference :3 was invoked but never defined (see the help page).
^Tsuji, K.; Nakamura, Y.; Ogata, T.; Mitani, A.; Kataoka, K.; Shibata, T.; Ishida, M.; Shinozaki, H. (1995-09-01). "Neurotoxicity of acromelic acid in cultured neurons from rat spinal cord". Neuroscience. 68 (2): 585–591. doi:10.1016/0306-4522(95)00149-d. ISSN 0306-4522. PMID 7477968. S2CID 45027663.
AcromelicacidA (ACRO A) is a toxic compound that is part of a group known as kainoids, characterized by a structure bearing a pyrrolidine dicarboxylic...
the paralysis cap and has been shown to contain acromelicacids including acromelicacidA which is a potent neurotoxin with the chemical formula of C13H14N2O7...
aspartic acid is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-aspartic acid is one of two D-amino acids commonly...
(symbol Ala or A), or α-alanine, is an α-amino acid that is used in the biosynthesis of proteins. It contains an amine group and a carboxylic acid group, both...
table 1. This table originates from the article ‘Acromelic frontonasal dysplasia: further delineation of a subtype with brain malformations and polydactyly...
(high levels of uric acid in the blood). All thiazide diuretics including hydrochlorothiazide can inhibit excretion of uric acid by the kidneys, thereby...
acid roGFP, a tool to measure the cellular glutathione redox potential Glutathione-ascorbate cycle Bacterial glutathione transferase Thioredoxin, a cysteine-containing...
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane...
acetamide. It is a cyclic derivative of the neurotransmitter GABA and shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid. Related drugs...
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Glutamic acid (symbol Glu or E; the anionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis...
or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified as a distinct receptor...
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics...
an α-amino acid that is used in the biosynthesis of proteins. Its side chain is similar to that of glutamic acid, except the carboxylic acid group is replaced...
"Biological effects of the dihydroorotate dehydrogenase inhibitor polyporic acid, a toxic constituent of the mushroom Hapalopilus rutilans, in rats and humans"...
2-Pyrrolidinone and p-anisic acid (20–30%). There is some preliminary research suggesting that N-anisoyl-GABA and to a lesser degree p-ansic acid may contribute to...
Kainic acid, or kainate, is an acid that naturally occurs in some seaweed. Kainic acid is a potent neuroexcitatory amino acid agonist that acts by activating...
4-chlorobenzoic acid. In the first stage of synthesis, it undergoes sulfonylchlorination by chlorosulfonic acid, forming 4-chloro-3-chlorosulfonylbenzoic acid, which...
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+...
"GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro". Molecular Therapy. Nucleic Acids. 17: 436–447...
Deoxymethoxetamine (3'-methyl-2-oxo-PCE, DMXE, 3D-MXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects...
Pentobarbital can occur as a free acid, but is usually formulated as the sodium salt, pentobarbital sodium. The free acid is only slightly soluble in...
Kynurenic acid (KYNA or KYN) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive...
to store energy and run a magnesium-based engine. Magnesium also reacts exothermically with most acids such as hydrochloric acid (HCl), producing magnesium...
Domoic acid (DA) is a kainic acid-type neurotoxin that causes amnesic shellfish poisoning (ASP). It is produced by algae and accumulates in shellfish,...
Products of this catabolic process include methoxyfluoroacetic acid (MFAA), dichloroacetic acid (DCAA), and inorganic fluoride. Methoxyflurane nephrotoxicity...
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