The 1968 United States Senate election in Maryland was held on November 5, 1968. Incumbent Democratic U.S. Senator Daniel Brewster ran for re-election to a second term in office but was defeated by Republican U.S. Representative Charles Mathias.
Mathias may have benefited from the campaign of George P. Mahoney, the 1966 Democratic nominee for Governor of Maryland, who ran on the George Wallace American Independent ticket and garnered a significant chunk of the vote.
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